Neuroinflammation and Neuron-Glia interactions

Our research group is interested in exploring immunopathogenesis of viral infections in the CNS, and to understand individual differences in susceptibility to neuroinfections in humans. We use genetic analysis of patients with severe outcome of HSV o

Mouse and cellular models for Glia-neuron interactions in the PNS in relation to neuropathy, and glia-to-neuron communication by exosomes

Clinical trials in neurooncology (phase 1 and 2). Preclinical studies on living tissue samples of human cerebral cortex and brain tumor (cellular electrophysiology). Computer models of tumor treating fields dose. Technology development

Research focused on energy metabolic interactions among glia and neurons in the healthy and diseased brain using primary and hIPSC-derived cultures, brain-derived preparations, dynamic metabolic mapping, mass spectrometry and bioenergetics

We are Investigating the interaction between environmental triggers, neuroinflammation, excitability and the neurodegenerative disease ALS-FTD (Amyotrophic Lateral Sclerosis and Frontal Temporal Dementia).

Research focused on energy metabolic interactions among glia and neurons in the healthy and diseased brain using primary and hIPSC-derived cultures, brain-derived preparations, dynamic metabolic mapping, mass spectrometry and bioenergetics

The lab investigates neuronal and glial microcircuitries of cortical structures in behaving mice using optical imaging and molecular genetics. We are aimed at discovering a new biological principle that may be central to neural plasticity.

We study multiple sclerosis and other immune-mediated diseases using: biomarker studies (ELISA, ECL, SIMOA) and gene expression assays (qPCR); genetic and epigenetic studies; T/B cell activation assays; and in vitro blood-brain barrier, astrocyte and

My laboratory is interested in identifying biomarkers relevant for detection and modulating of inflammatory processes and synaptic plasticity in patients with neurodegenerative diseases as well as in relevant animal models of disease.

Primary focus is immune regulation, including how the immune-neuro axis modulates immune responses. Our methods are molecular and cell based and include flow cytometry, RNAseq (bulk and scRNA), ATAC, cut&run

Our lab is focused on study of astrocytes. The two major lines of work focuses on 1) neuroglia interactions and 2) the glymphatic fluid transport and how both are regulated by the sleep-wake cycle and differeny states of brain activity

ImmunoPsychiatry and Precision Psychiatry – through the use of Big Data from nationwide registers and large-scale genetics, to deeply phenotyped clinical data, including cerebrospinal fluid investigations, with the aim of discovering biological meani

Investigation of 1) neuroprotective and immunomodulatory mechanisms driven by microglia in neurological diseases such as Multiple Sclerosis (MS), Alzheimer’s disease and normal aging. 2) the role of placental cells and microchimerism in pregnancy-ass

Investigating the Innate regulation of neuroinflammation and the role of glial and myeloid cells in demyelinating diseases; in vivo models, drugs and treatments, Flow cytometry, histology, and molecular analysis

Investigation of 1) neuroprotective mechanisms driven by microglia in neurological diseases such as Multiple Sclerosis (MS), Alzheimer’s disease 2) the role of placenta and microchimerism in pregnancy-associated remission from MS.

We are studying biomarkers- proteins that predict onset, disease worsening or reactions to medications. Biomarkers can also give an understanding of disease mechanisms. We use patient material, animals, cell cultures, analyzed using molecular methods

Unravel and modulate the inflammatory response orchestrated by innate immune cells in the brain post-stroke. We perform drug testing and cell therapies, emphasizing findings relevant to cell function, cell communication, and stroke pathophysiology.

Optimizing patient outcome after neurosurgical treatments. The diseases in question range from brain cancer, cerebral metastasis to vascular disorders and neurodegenerative diseases. Acute and elective.

Our research mainly focuses on neuroinflammatory diseases, and we use a wide range of experimental in vitro and in vivo models, clinical samples, as well as postmortem tissue, to study cellular and molecular mechanisms.

The research has translational goals, integrating clinical and experimental studies on inflammatory demyelinating diseases of the CNS. Methodologies include OCT, murine disease models, analysis of human tissues and CSF samples by sensitive assays.

We aim understanding neuroimmune mechanisms in Alzheimer’s, focusing on modulation of microglia to prevent an ameliorate pathology. We also investigate the immune contribution to white matter de(re)generation in Alzheimer’s and multiple sclerosis.

Animal models for MS and NMOSD; EAE, cuprizone, intrathecal cytokines; flow cytometry, RT-qPCR, histology, RNAseq.