Motor and Pain Neuroscience

Nociceptive pain, temperature and pain perception, human neuroimaging

Neuromuscular function in health and disease with particular focus on neuromuscular diseases

We develop and apply probabilistic models of brain activity to understand how information is processed in the brain, and how this shapes and is shaped by endogeneous activity. We use a wealth of data modalities, including fMRI, M/EEG and LFP.

Clinical research involving patients with neuropathic pain due central or peripheral nervous system lesion and experimental pain models (randomized clinical trials, pharmacology, sensory testing, neurophysiology, molecular biology)

The research aim is to understand how brainstem neurons control breathing. We use electrophysiological and optical techniques to study neurons under in vitro conditions, where the basic circuit producing breathing pattern is intact and functional.

Nervelab bridges studies between the Department of Clinical Neurophysiology, Rigshospitalet and University of Copenhagen. At Neuroscience we carry out translational studies on the relationship between electrical function and survival of axons.

We focus on and enjoy creating new directions of gene therapy. We do this by engineering recombinant peptides that target various proteins not regarded as conventional brain drug targets, and apply them to rodent disease models.

Translational research in malignant and non-malignant bone pain. Rodent models of cancer-induced bone pain and other bone diseases. Pain-related behavioural outcome measures. In vivo imaging. Ex vivo and in vitro analyses Pain phenotyping of patients

Neural principles behind movement

Our goal is to understand how two main determinants of physical function, motoneurone input and muscle attachment to the skeleton, are affected during the ageing process, and how physical activity can counteract some of the negative changes.

Motor learning and neuroplasticity. Development of gait ability. Rehabilitation of motor function following brain injuries in children, youth and adults. Mechanisms underlying improved function in relation to rehabilitation.

I study cognition e.g. intentions, perception and prediction, of sensorimotor integration in human motor control, using data from brain and body electrophysiology (EEG, EMG, TMS), behavior, eye- & motion-tracking combined in computational models.

I explore the effects of electroceutical therapy on brain activity using fMRI and PET. I apply Deep Brain Stimulation (DBS), Transcutaneous Nerve Stimulation (TENS) and Vagus Nerve Stimulation (VNS) in both preclinical (pigs) and clinical studies.

I aim to establish transcranial brain stimulation as an effective medical treatment by personalizing stimulation methods and introducing new stimulation approaches. I integrate brain stimulation with brain imaging and develop new dose control methods

We study with electrophysiological, molecular, and behavioral analysis the mammalian nervous system to understand the organization of neuronal circuits that execute movement and the possibilities to restore motor function caused by trauma or disease

Combination of human cell culture work with clinical studies to understand mechanisms of peripheral nervous system toxicity caused by chemotherapeutics