Brain States and Brain-Body Interactions

Overarching theme: epilepsy & clinical neurophysiology. Sub-topics: electromagnetic source imaging; automated & semiautomated analysis in clinical practice using AI; quality assurance & standardisation in clinical neurophysiology; seizure detection.

We study interoception, decision-making, and brain-body interaction.

We investigate communication between neural structures such as cortex and retina using human neurophysiological techniques (primarily MEG and optically pumped magnetometers). We recently launched neurodevelopmental research using fetal MEG with OPMs.

Neurobiology of the gut-brain axis in zebrafish. We use light-sheet microscopy and calcium imaging to record the neuronal activity of live animals at the systems level. We plan to study the impact of autism on the microbiome.

We use a combination of intestinal cell and organoid cultures, molecular biology, genetics, functional imaging, and electrophysiology methods to study the cellular mechanisms underlying neurosecretion from cells in the gut that signal to the brain

Our lab’s goal is to understand the neuronal mechanisms involved in memory and cognition and how imbalances in the circuits can lead to pathological conditions. In particular, we study spatial memory, and theta oscillations in behaving rats, and how

I am investigating the role of astrocytes and anions in inhibitory transmission. I explore how different brain states and behaviour are influenced by manipulation or malfunction of astrocytes and ionostasis.

Developing chronotherapeutic and neurostimulation methods for depression and sleep, including light and electromagnetic exposure systems, sleep manipulations, psychoeducation, and research into zeitgebers impact on the circadian neurohormonal system

We study the molecular basis for action potential generation. Using primary neurons and various biochemical and imaging techniques, we dissect the molecular architecture and plasticity underlying this major decision-making process in a nerve cell.

We focus on brain mechanisms underlying obesity and type 2 diabetes. Our team includes neuroscientists, data scientists and geneticists, and leverages transgenic animals models, single-cell sequencing, machine learning and data science techniques.

We study body weight homeostasis and develop new therapeutic strategies for treatment of obesity and neurodegenerative diseases, such as Alzheimer’s. Our research approach is truly translational, involving c elegans, mouse models and human studies

We study the sleep-wake balance and how it is affected by the immune system during viral infections and in the sleep disorder narcolepsy. We measure sickness behavior and sleep states, use molecular biology, single cell technology, and animal models.

My research focuses on how sleep shapes cognitive performance. I explore how sleep microstructure shapes restorative sleep processes related to both memory consolidation and waste clearance as well as therapeutic strategies.

Intracellular organelle transport is critically important for development, homeostasis and function of neurons due to their extreme polarity and size. Our current focus is the molecular mechanisms of axonal transport, studied in Drosophila.

I am chair of NRU (www.nru.dk) which covers many neurobiological research topics. My research focus is on psychedelics and neuroplasticity; I use neuroimaging with PET-MR, novel radioligands in pigs, and study the brain in volunteers and patients.

We use state-of-the-art fluorescence microscopy to image the distribution, structure and function of signalling proteins at the plasma membrane, with single molecule resolution. Emphasis is on GPCRs and neurotransmitter transporters.

Circadian neurobiology: In a combined effort, involving molecular, cellular, surgical and neuroanatomical techniques, our aim is to of determine physiological and molecular regulatory mechanisms of circadian 24h brain function.