Brain Vasculature and Barriers

The Blood Flow Imaging group focuses on developing and applying novel imaging technologies for diagnostics and characterization of the microcirculation condition.

Brain perfusion imaging in awake rodents; Neurovascular coupling in brain slices to assess responses in neurons, astrocytes and blood vessels; Ischemic stroke models; Electrophysiology; Spatial omics of brain

We aim to understand the molecular and physiological mechanisms behind cerebrospinal fluid (CSF) secretion and pH regulation by the choroid plexus. We us a combination of in vivo and ex vivo methods ranging from mouse to primary culture.

High field MRI of awake rodents for brain research.

Exploring and exploiting extracellular vesicles (EVs) and miRNAs in stroke diagnostics and treatment. In collaboration with the clinic, we study the diagnostic potential of EVs/miRNAs and test their treatment potential in different cellular models

Stroke models; imaging of ion dynamics (pH, Ca2+); microdialysis-based metabolite measurements; electrode-based extracellular pH, CO2 & O2 recordings; resistance artery myography; stereological evaluation of vasculature; expression of mRNA & protein

Development and evaluation of advanced x-nuclei MRI for neuro applicaitons

The research focus is ion transport mechanisms in CSF secretion by the choroid plexus. The methods include live cell ion imaging and ion sensitive electrodes, immunohistochemistry, and drug design targeting CSF secretion.

I study neurovascular coupling and capillary (dys)function in dementia and stroke using PET and MRI in humans, optical imaging methods in rodent models, and by biophysical modeling.

We look at receptor mediated transport at Blood brain barrier, using primary cells and iPSC.

Stroke, small vessel disease, vascular/endothelial dysfunction. Neuro-recovery processes and rehabilitation. Bench to bedside collaborative research. MRI, TCD, cardiovascular and cognitive function, register, AI and new technology. Clinical trials.

Drug delivery to the brain is restricted by biological barriers such as the blood-brain barrier, the nose-to-brain barrier and ependymal barriers. We study these barriers at the cellular level and identify pathways and drugs for brain delivery.

Probing neurovascular coupling in cognitive decline using functional MRI (ASL/BOLD with hypercapnic challenge). Measuring GI-reflexes following ingestion using phase-contrast MRI. Relating findings to clinical characterization.

In vivo studies with telemetry system to measure intracranial pressure (ICP) with the aim to understand ICP regulation and elevated ICP in animal model for Idiopathic Intracranial Hypertension (IIH).Focus on disease mechanism and IIH-related headache

Key techniques: Human provocation models; structural, functional, and metabolic magnetic resonance imaging; blood-based biomarker investigations; quantitative sensory testing

Clinical studies in child- and adolescent mental disorders, psychosis and OCD. Involved in translational studies investigating the neurobiological/neurocognitive/neuroendocrine underpinnings of disease and treatment response

My research deals with cerebral blood flow, the function of the brain and brain imaging, primary MR, but also SPECT and PET. Physiology and degrative diseases. Regulatory mechanisms include neurotransmitter and also the renin-angiotensin system.

The stroke project relates to finding a way to stop the upregulation of contractile receptors, vascular inflammatin and blood-brain barrier opening. When this is done early it prevents the development of the ischemic brain injury projects of highest

The research focuses on molecular pharmacological characterization of brain targets in neuroprotection and -repair. Of main interest is the therapeutical potential of targets for GABA, its metabolite GHB, and the calmodulin-responsive kinase CaMKII.

Clinical stroke research (including large clinical trials, cognitive interventions, stroke epidemiology). Areas of specific interest include intracerebral hemorrhage, oral anticoagulant related intracerebral hemorrhage, sex-differences.

In vivo/in vitro determination of cerebrospinal fluid secretion

Mapping and shaping causal dynamics of human brain networks in health & disease (Parkinson´s disease, multiple sclerosis, stroke, psychiatric disorders) combining psychophysics, functional and structural MRI, EEG, and transcranial brain stimulation.

Extensive knowledge of brain microcirculation and the BBB, particularly how cell components and small molecules regulate and modulate the BBB, as well as the role of antibodies to promote BBB crossing by transcytosis.

My research interests are to unravel the mechanisms underlying motor deficits and cardiovascular disfunctions after traumatic spinal cord injury and brain injury using multiple behavioral, cellular, and molecular neurobiology techniques.