NAD Fellow year: 2024

Adrian Gjetnes Rossebø

MSc in Medical Chemistry, University of Copenhagen

Lab rotations - pre-PhD year

Lab Rotation 1

Bioanalytical Unit, Department of Forensic Medicine, Aarhus University w/PI Associate Professor Steffen Sinning

During his rotation, Adrian is working on methods to achieve high spatiotemporal control of the activity of serotonin 2A receptor subtype in order to understand the molecular mechanism underlying hallucinations and fast antidepressant action via this receptor.

Lab Rotation 2

Neurobiology Research Unit, Rigshospitalet w/PI Professor Gitte Moos Knudsen

Adrian is learning to do autoradiography studies on brain slices and is taking part in projects involving PET- and MR-scanning of pigs. The goal is that he will be able to radiolabel and test his radioligand production in vitro and in vivo.

Lab Rotation 3

Sørensen Lab, Department of Neuroscience, University of Copenhagen w/PI Jakob Professor Jakob Balslev Sørensen

Meet Adrian Gjetnes Rossebø

For Adrian Gjetnes Rossebø, research is a voyage of discovery – and he is excited to embark on his PhD journey to explore his interests in pharmacology and psychiatric disorders.

Adrian Gjetnes Rossebø completed his master’s degree in Medicinal Chemistry from the University of Copenhagen in 2023 in the Jesper L. Kristensen group at the Department of Drug Design and Pharmacology at the University of Copenhagen.  Adrian’s thesis was part of an early-stage research project in developing tools for investigating psychedelics and their therapeutic effects:

“My master’s thesis was about making photoswitchable ligands for the 5-HT2A receptor. (…) We know that psychedelics can have quite fast-working antidepressive effects. In that context, it is important to investigate whether it works or does not work in a clinical sense, but it is also important to understand the underlying mechanisms: why do these drugs have an antidepressive effect. And this is where my thesis came into play. The idea is that you would be able to – in vitro and hopefully in vivo – turn the activity of these drugs on and off, and use that to investigate different signalling cascades or phenomena such as neuroplasticity,” Adrian explains.

As someone coming from the medicinal chemistry field, Adrian is excited about using the pre-PhD year to gain a fundamental neuroscience basis:

“The pre-PhD year is pretty unique. Especially for someone like me, who is coming from a medicinal chemistry background, it is very useful to have this year in which I can obtain a substantial amount of neuroscience knowledge as well as experience how researchers work within the field,” Adrian says.

Growing up, Adrian dreamt of becoming an inventor, but later on, he found that he was not as interested in inventing as he was in the act of discovery: learning new things and understanding the fundamental aspects of our world. Naturally, this drew him into research.

Adrian will do his first rotation with Professor Steffen Sinning at Aarhus University, where he will try his hands at protein expression and pharmacological functional assays as well as build on some of the findings from his master’s thesis.