Lab rotations - pre-PhD year
Lab Rotation 1
Danish Dementia Research Centre, Copenhagen University Hospitals – Rigshospitalet w/PI Professor Jørgen Erik Nielsen
During her lab rotation in the group of Jørgen E. Nielsen, Tulieca will gain hands-on experience with dedifferentiation of fibroblasts to induced pluripotent stem cells (iPSC) from patients with Alzheimer’s Disease followed by verification of reprogramming with tri-lineage differentiation. Additionally, she will participate in all lab meetings and be introduced to the ongoing projects within the lab. As part of her lab rotation, she will also participate in consultations with patients at the memory clinic.
Meet Tulieca Jeyaseelan
Curiosity-driven and not one to turn down a challenge, Tulieca Jeyaseelan loves neuroscience for its complexity and unanswered questions – and for the intricate and mysterious connections between brain and body.
Tulieca Jeyaseelan completed her master’s degree in Molecular Medicine from Aarhus University in 2023. Since then, she has been working as a research assistant in the Paludan Group at the Department of Biomedicine at Aarhus University, focusing on HSV-1 infection in the brain.
Broadly, Tulieca is interested in inflammation and neurodegenerative diseases:
“For me, one of the biggest questions has always been why the immune system, which is there to protect our bodies, can be the culprit when it comes to some diseases. It interests me that neurodegenerative diseases might not just be diseases of the brain, but in fact diseases that involve the entire body,” Tulieca explains.
During her education, Tulieca has been working within the field of neurodegenerative diseases. During her bachelor’s, she was focused on Alzheimer’s disease and blood-brain barrier integrity. For her master’s thesis in the CNS Disease Modelling Group at Aarhus University, she investigated how the peripheral immune system is activated in Parkinson’s disease patients.
For her first rotation, Tulieca will join the group of Jørgen Erik Nielsen at the Danish Dementia Research Centre, and she is excited to try working in a more clinically oriented setting than she is used to. For one of her later rotations, Tulieca would like to gain experience within omics as she finds this group of methods to hold great potential for future research in the field.
One of the main reasons Tulieca applied for an NAD fellowship is the autonomy the programme provides:
“I have never doubted that I wanted to pursue a PhD degree. For me, the motivation has to be there, and for the motivation to be there, it has to be a good project. The NAD programme is a unique opportunity to tailor-make a project that fits you really well,” Tulieca explains.
Tulieca loves a challenge, and one of the things she finds most interesting about neuroscience is its many unanswered questions:
“I am a very curious person. There are so many things we do not know anything about, and I think that one of the biggest mysteries I have been introduced to is the brain. (…) I have a lot of research questions I would like to answer, and as long as there are questions to resolve, I would like to stay in the field,” Tulieca says.